Abstract: As a significant non-carbon-based energy source, the exploration and development of medium-deep hydrothermal geothermal resources are characterized by high technical barriers and substantial investment risks. Developing a systematic set of preferential evaluation indicators is crucial for the effective exploration and assessment of geothermal resources. Taking the Changsha–Zhuzhou–Xiangtan area of Hunan Province as the study region, the study systematically integrated multi-source information, including heat source conditions (Curie surface depth, geothermal gradient, terrestrial heat flow), geothermal reservoir conditions (lithology, geothermal storage capacity, heat production rate), geological structure types, channel conditions (deep faults, secondary faults), hydrogeological conditions (hot spring discharge, rainfall), geothermal water chemistry (SiO₂ content), and geothermal temperature. An information quantification evaluation model based on fractal theory was constructed to predict the potential zoning of geothermal resources in the study area. The favorable target area in the study area needs to have a number of comprehensive geological conditions: the terrestrial heat flow value is 68.5–77.0 mW/m², the geothermal gradient is 2.87–3.17 ℃/hm; the structure is located in the conversion and superposition area of the basin and the depression, and is in the 2−3 km influence zone of the deep fault. The reservoir should be buried carbonate rock with SiO₂ mass fraction > 96.47% and water inflow > 2439.2 m³/d. The reservoir temperature > 86.5 ℃.The geothermal potential zones in the Changsha–Zhuzhou–Xiangtan area belong to different tectonic units and geothermal reservoir types. The Weishan uplift, Wangxiang uplift, and Yanling uplift are all granite-fractured geothermal reservoirs, with average terrestrial heat flow values of 73.06, 65.26, and 94.10 mW/m², respectively. The Changsha and Zhuzhou faulted basins are fracture-karst geothermal reservoirs composed of carbonate rocks/quartz sandstones, with an average terrestrial heat flow value of 72.36 mW/m². The geothermal enrichment in these areas is controlled by local basement uplifts. The Xiangtan depression basin and the Baishi-Chaling depression basin are represented by carbonate karst fissure-type thermal reservoirs, which are obviously controlled by east-west and north-east faults. The former has a higher geothermal reservoir temperature, while the latter shows a deeper rock mass heat generation background and shallower groundwater circulation depth characteristics. It is recommended to prioritize exploration in basin-depression transition and superimposed areas where the lithology consists of buried carbonate rocks. The research findings not only serve the geothermal exploration practice in the Changsha-Zhuzhou-Xiangtan area, but also provide a reference for the evaluation of medium-deep hydrothermal geothermal resources in similar geological mountain uplift regions in China.