Abstract: With the advancement of the dual carbon goals, how to achieve coordinated and optimized scheduling among multiple mining areas and enhance the overall low-carbon and economic performance of mining groups has become an urgent issue to be addressed. A multi-agent coordinated optimization operation method for the integrated energy system of mines under a two-level game mechanism is proposed. Firstly, based on the efficient utilization of mine-derived resources, a low-carbon integrated energy operation framework for mines is constructed. Combining the energy consumption characteristics of mine production and life, a two-level game model at the mining area level is established, with the aggregator service provider as the upper-level decision-maker and the energy suppliers and users as the lower-level executors. Secondly, according to the distribution characteristics of mining areas, two mining areas with typical features are selected to propose a multi-mining area coordinated operation method. The aggregator service provider manages the overall output of the integrated energy system within the mines, is responsible for energy and carbon trading with the upper-level power grid and carbon market, and formulates the internal energy prices of the mining areas. Users and energy suppliers determine and feedback the energy supply and consumption strategies based on the price information and adjust the energy interaction between mining areas. Finally, a stepwise carbon trading mechanism is introduced, and the adaptive differential algorithm is adopted, combined with the CPLEX solver to solve the model. Considering the interests of all parties, the energy transaction prices within the mining areas and between mining areas are optimized to achieve the maximization of mining area benefits under this model. Based on the actual data of a comprehensive energy station in a certain mining area in Ningxia, a developed mature mining area with complete new energy power generation facilities and an expanding high-concentration gas mining area with high production load energy demand and a small proportion of new energy development are selected to set up a multi-mining area integrated energy coordinated operation scenario to verify the effectiveness of the proposed model. The simulation results show that the proposed model effectively coordinates multiple mining area integrated energy systems, overcomes the limitation that a single dispatch cannot meet the energy demands of multiple energy users, and comprehensively improves the overall new energy and associated energy consumption capacity of multiple mining areas. Compared with the independent operation of mining areas, the overall revenue of the mining area cluster is increased by 48.45% and the total carbon emissions are reduced by 7.71% with the proposed method, thereby improving the economic and low-carbon performance of energy operation in clustered mining areas.